Drug interactions
Nifedipine + Sotalol
Severity: Minor
Nifedipine and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pair is often used together and lowers blood pressure additively. Beta-blockade blunts nifedipine reflex tachycardia, but hypotension or heart failure worsening can occur in vulnerable patients.
What this interaction means in plain words
Nifedipine and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-blockade and dihydropyridine vasodilation.
What to do
Monitor blood pressure and signs of heart failure when starting or titrating. Reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Sotalol?
MediHelp rates the interaction as minor. Nifedipine and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The pair is often used together and lowers blood pressure additively. Beta-blockade blunts nifedipine reflex tachycardia, but hypotension or heart failure worsening can occur in vulnerable patients.
How serious is the interaction between Nifedipine and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and signs of heart failure when starting or titrating. Reduce doses if symptomatic hypotension develops.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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