Drug interactions
Nifedipine + Stiripentol
Severity: Moderate
Nifedipine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so nifedipine exposure may be altered unpredictably. Either excess hypotension or reduced efficacy could occur.
What this interaction means in plain words
Nifedipine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits and induces CYP3A4, altering nifedipine clearance in an unpredictable direction.
What to do
Monitor blood pressure and clinical response after starting or stopping stiripentol and adjust the nifedipine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Stiripentol
Frequently asked questions
Can I take Nifedipine with Stiripentol?
MediHelp rates the interaction as moderate. Nifedipine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so nifedipine exposure may be altered unpredictably. Either excess hypotension or reduced efficacy could occur.
How serious is the interaction between Nifedipine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response after starting or stopping stiripentol and adjust the nifedipine dose accordingly.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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