Drug interactions
Nifedipine + Temsirolimus
Severity: Moderate
Nifedipine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, and nifedipine is only a weak inhibitor. There are reports that mTOR inhibitors combined with calcium channel blockers raise the risk of angioedema.
What this interaction means in plain words
Nifedipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by nifedipine plus a possible additive pharmacodynamic contribution to angioedema.
What to do
Counsel patients to report swelling of the lips, tongue or face immediately. Stop one of the drugs if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Nifedipine with Temsirolimus?
MediHelp rates the interaction as moderate. Nifedipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, and nifedipine is only a weak inhibitor. There are reports that mTOR inhibitors combined with calcium channel blockers raise the risk of angioedema.
How serious is the interaction between Nifedipine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the lips, tongue or face immediately. Stop one of the drugs if angioedema develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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