Drug interactions
Nifedipine + Trazodone
Severity: Minor
Nifedipine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is metabolized by CYP3A4, but nifedipine is a weak inhibitor, so a major rise in levels is unlikely. Both drugs can cause hypotension, and trazodone has alpha-blocking activity that adds to the effect.
What this interaction means in plain words
Nifedipine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive hypotension, with possible weak CYP3A4 inhibition by nifedipine.
What to do
No routine dose change is needed. Monitor for dizziness and orthostatic hypotension, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Nifedipine with Trazodone?
MediHelp rates the interaction as minor. Nifedipine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone is metabolized by CYP3A4, but nifedipine is a weak inhibitor, so a major rise in levels is unlikely. Both drugs can cause hypotension, and trazodone has alpha-blocking activity that adds to the effect.
How serious is the interaction between Nifedipine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness and orthostatic hypotension, especially in older patients.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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