Drug interactions
Nilotinib + Ozanimod
Severity: Major
Nilotinib and Ozanimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect cardiac conduction: nilotinib prolongs the QT interval, and ozanimod can slow heart rate. Together they may raise arrhythmia risk, especially with bradycardia.
What this interaction means in plain words
Nilotinib and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization with ozanimod-related bradycardia.
What to do
Avoid starting ozanimod in patients taking nilotinib unless a cardiologist advises. If it is used, obtain a baseline ECG and monitor heart rate and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Nilotinib with Ozanimod?
MediHelp rates the interaction as major. Nilotinib and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can affect cardiac conduction: nilotinib prolongs the QT interval, and ozanimod can slow heart rate. Together they may raise arrhythmia risk, especially with bradycardia.
How serious is the interaction between Nilotinib and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients taking nilotinib unless a cardiologist advises. If it is used, obtain a baseline ECG and monitor heart rate and QTc.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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