Drug interactions
Nilotinib + Ranolazine
Severity: Contraindicated
Nilotinib and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and can raise ranolazine levels. Both drugs prolong the QT interval, so the combination raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Nilotinib and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation with CYP3A4 and P-glycoprotein inhibition by nilotinib increasing ranolazine exposure.
What to do
Do not combine; choose a non-QT-prolonging antianginal during nilotinib therapy. If unavoidable, obtain ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nilotinib and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Ranolazine?
MediHelp rates the interaction as contraindicated. Nilotinib and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib inhibits CYP3A4 and P-glycoprotein and can raise ranolazine levels. Both drugs prolong the QT interval, so the combination raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Nilotinib and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-QT-prolonging antianginal during nilotinib therapy. If unavoidable, obtain ECG monitoring and correct electrolytes.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
