Drug interactions
Nilotinib + Stiripentol
Severity: Moderate
Nilotinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein and may raise nilotinib levels, although it can also induce CYP3A4. Because of this, the net effect on nilotinib exposure is unpredictable, with a risk of QT prolongation if exposure rises.
What this interaction means in plain words
Nilotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 (inhibition and induction) and inhibits P-gp, altering nilotinib disposition.
What to do
Obtain an ECG and monitor for nilotinib toxicity or loss of response, and adjust the nilotinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Nilotinib with Stiripentol?
MediHelp rates the interaction as moderate. Nilotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-glycoprotein and may raise nilotinib levels, although it can also induce CYP3A4. Because of this, the net effect on nilotinib exposure is unpredictable, with a risk of QT prolongation if exposure rises.
How serious is the interaction between Nilotinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and monitor for nilotinib toxicity or loss of response, and adjust the nilotinib dose as needed.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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