Drug interactions
Nilotinib + Temsirolimus
Severity: Moderate
Nilotinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is converted to sirolimus, a CYP3A4 substrate, and nilotinib may raise levels of these compounds. This can increase mTOR inhibitor toxicity such as stomatitis, cytopenias and metabolic effects.
What this interaction means in plain words
Nilotinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism by nilotinib.
What to do
Monitor for temsirolimus toxicity and blood counts, and reduce the dose if adverse effects emerge. Monitor QTc because of nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Nilotinib with Temsirolimus?
MediHelp rates the interaction as moderate. Nilotinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus is converted to sirolimus, a CYP3A4 substrate, and nilotinib may raise levels of these compounds. This can increase mTOR inhibitor toxicity such as stomatitis, cytopenias and metabolic effects.
How serious is the interaction between Nilotinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and blood counts, and reduce the dose if adverse effects emerge. Monitor QTc because of nilotinib.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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