Drug interactions
Nilotinib + Tramadol
Severity: Moderate
Nilotinib and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may inhibit CYP2D6, reducing conversion of tramadol to its active metabolite and altering the balance between opioid and monoaminergic effects. Both drugs can also prolong the QT interval or lower seizure threshold to some degree, so overall tolerability may be affected.
What this interaction means in plain words
Nilotinib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Possible CYP2D6 inhibition by nilotinib reduces tramadol activation; nilotinib also has QT-prolonging effects.
What to do
Monitor analgesic response and ECG/QT in patients with other risk factors. Consider an alternative analgesic if QT risk is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Tramadol?
MediHelp rates the interaction as moderate. Nilotinib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may inhibit CYP2D6, reducing conversion of tramadol to its active metabolite and altering the balance between opioid and monoaminergic effects. Both drugs can also prolong the QT interval or lower seizure threshold to some degree, so overall tolerability may be affected.
How serious is the interaction between Nilotinib and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and ECG/QT in patients with other risk factors. Consider an alternative analgesic if QT risk is a concern.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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