Drug interactions
Nilotinib + Triclabendazole
Severity: Major
Nilotinib and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so taking them together may increase the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or underlying heart disease.
What this interaction means in plain words
Nilotinib and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and correct potassium and magnesium before treatment. Monitor ECG during co-therapy, or defer triclabendazole if the QTc is already prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Nilotinib with Triclabendazole?
MediHelp rates the interaction as major. Nilotinib and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so taking them together may increase the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or underlying heart disease.
How serious is the interaction between Nilotinib and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before treatment. Monitor ECG during co-therapy, or defer triclabendazole if the QTc is already prolonged.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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