Drug interactions
Nilotinib + Valbenazine
Severity: Major
Nilotinib and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and nilotinib has a boxed warning for QT prolongation. Using them together may add to arrhythmia risk.
What this interaction means in plain words
Nilotinib and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; nilotinib CYP3A4 inhibition may also raise valbenazine metabolite exposure.
What to do
Obtain a baseline ECG and correct electrolytes, then monitor the QTc during co-therapy. Avoid the combination in patients with congenital long QT syndrome or other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Nilotinib with Valbenazine?
MediHelp rates the interaction as major. Nilotinib and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valbenazine can prolong the QT interval at higher exposures, and nilotinib has a boxed warning for QT prolongation. Using them together may add to arrhythmia risk.
How serious is the interaction between Nilotinib and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes, then monitor the QTc during co-therapy. Avoid the combination in patients with congenital long QT syndrome or other QT risk factors.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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