Drug interactions
Nimodipine + Nitroglycerin
Severity: Moderate
Nimodipine and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nimodipine and nitroglycerin both lower blood pressure by vasodilation, and combined use can lead to additive hypotension. This matters in subarachnoid hemorrhage, where hypotension can compromise cerebral perfusion.
What this interaction means in plain words
Nimodipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nimodipine belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilation through nitric oxide-mediated venous dilation and calcium channel blockade-mediated arterial dilation.
What to do
Monitor blood pressure closely, particularly in subarachnoid hemorrhage patients; split nimodipine dosing or lower the dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nimodipine with Nitroglycerin?
MediHelp rates the interaction as moderate. Nimodipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nimodipine and nitroglycerin both lower blood pressure by vasodilation, and combined use can lead to additive hypotension. This matters in subarachnoid hemorrhage, where hypotension can compromise cerebral perfusion.
How serious is the interaction between Nimodipine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, particularly in subarachnoid hemorrhage patients; split nimodipine dosing or lower the dose if hypotension develops.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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