Drug interactions
Nimodipine + Ribociclib
Severity: Moderate
Nimodipine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and can increase nimodipine exposure, with a risk of excessive hypotension, edema and headache. Ribociclib itself prolongs the QT interval, so careful overall monitoring is needed.
What this interaction means in plain words
Nimodipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nimodipine belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing nimodipine metabolism.
What to do
Monitor blood pressure and heart rate, and reduce the nimodipine dose if hypotension develops. Consider an alternative if the patient has a narrow hemodynamic margin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Nimodipine with Ribociclib?
MediHelp rates the interaction as moderate. Nimodipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and can increase nimodipine exposure, with a risk of excessive hypotension, edema and headache. Ribociclib itself prolongs the QT interval, so careful overall monitoring is needed.
How serious is the interaction between Nimodipine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the nimodipine dose if hypotension develops. Consider an alternative if the patient has a narrow hemodynamic margin.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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