Drug interactions
Nintedanib + Phenytoin
Severity: Moderate
Nintedanib and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces P-glycoprotein and CYP3A4 and may reduce nintedanib exposure, possibly weakening its antifibrotic effect.
What this interaction means in plain words
Nintedanib and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Induction of P-glycoprotein and CYP3A4 by phenytoin lowers nintedanib absorption and increases clearance.
What to do
Where possible, choose an anticonvulsant without inducing properties. If combined, monitor clinical response and pulmonary function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Phenytoin?
MediHelp rates the interaction as moderate. Nintedanib and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces P-glycoprotein and CYP3A4 and may reduce nintedanib exposure, possibly weakening its antifibrotic effect.
How serious is the interaction between Nintedanib and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, choose an anticonvulsant without inducing properties. If combined, monitor clinical response and pulmonary function.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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