Drug interactions
Nintedanib + Propranolol
Severity: Minor
Nintedanib and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol may inhibit P-glycoprotein, the efflux transporter that limits nintedanib absorption and promotes its elimination. This could raise nintedanib exposure and increase gastrointestinal and hepatic adverse effects. The clinical significance is likely small and the evidence is largely predicted.
What this interaction means in plain words
Nintedanib and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nintedanib belongs to Oncology; Propranolol belongs to Cardiovascular.
Why it happens
Possible weak P-glycoprotein inhibition by propranolol reduces nintedanib efflux and may increase its exposure.
What to do
No empirical dose change is needed; monitor for diarrhea, nausea and liver enzyme elevation. Reduce the nintedanib dose or interrupt treatment if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Propranolol?
MediHelp rates the interaction as minor. Nintedanib and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol may inhibit P-glycoprotein, the efflux transporter that limits nintedanib absorption and promotes its elimination. This could raise nintedanib exposure and increase gastrointestinal and hepatic adverse effects. The clinical significance is likely small and the evidence is largely predicted.
How serious is the interaction between Nintedanib and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for diarrhea, nausea and liver enzyme elevation. Reduce the nintedanib dose or interrupt treatment if adverse effects develop.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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