Drug interactions
Nintedanib + Ulipristal
Severity: Moderate
Nintedanib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is a P-glycoprotein inhibitor and may raise nintedanib exposure, which is a P-gp substrate. Higher nintedanib levels could increase gastrointestinal adverse effects and liver enzyme elevations.
What this interaction means in plain words
Nintedanib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux, increasing nintedanib absorption and reducing its clearance.
What to do
Monitor for diarrhea, nausea and liver enzyme elevations, and consider nintedanib dose reduction or interruption if adverse effects occur. Since ulipristal is a single-dose emergency contraceptive, the effect is expected to be short-lived.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Ulipristal?
MediHelp rates the interaction as moderate. Nintedanib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is a P-glycoprotein inhibitor and may raise nintedanib exposure, which is a P-gp substrate. Higher nintedanib levels could increase gastrointestinal adverse effects and liver enzyme elevations.
How serious is the interaction between Nintedanib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, nausea and liver enzyme elevations, and consider nintedanib dose reduction or interruption if adverse effects occur. Since ulipristal is a single-dose emergency contraceptive, the effect is expected to be short-lived.
What other medicines interact with Nintedanib?
MediHelp also lists interactions of Nintedanib with, for example, Amiodarone, Apixaban, Argatroban. The full list is on the Nintedanib page.
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