Drug interactions
Nisoldipine + Prednisone
Severity: Minor
Nisoldipine and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is at most a weak CYP3A4 inducer, so a clinically significant fall in nisoldipine levels is not expected. Corticosteroids may cause fluid retention and raise blood pressure, which could oppose the antihypertensive effect.
What this interaction means in plain words
Nisoldipine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nisoldipine belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction; steroid-related sodium retention may oppose antihypertensive effect.
What to do
Monitor blood pressure during prednisone therapy and adjust nisoldipine if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Prednisone?
MediHelp rates the interaction as minor. Nisoldipine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prednisone is at most a weak CYP3A4 inducer, so a clinically significant fall in nisoldipine levels is not expected. Corticosteroids may cause fluid retention and raise blood pressure, which could oppose the antihypertensive effect.
How serious is the interaction between Nisoldipine and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prednisone therapy and adjust nisoldipine if control worsens.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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