Drug interactions
Nisoldipine + Secobarbital
Severity: Major
Nisoldipine and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may markedly lower nisoldipine levels, since nisoldipine has extensive first-pass CYP3A4 metabolism. Antihypertensive or antianginal effect may be lost.
What this interaction means in plain words
Nisoldipine and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nisoldipine belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of intestinal and hepatic CYP3A4 increases nisoldipine metabolism.
What to do
Avoid the combination if possible; labeling for nisoldipine advises against strong inducers. If used, monitor blood pressure and titrate the dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Secobarbital?
MediHelp rates the interaction as major. Nisoldipine and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may markedly lower nisoldipine levels, since nisoldipine has extensive first-pass CYP3A4 metabolism. Antihypertensive or antianginal effect may be lost.
How serious is the interaction between Nisoldipine and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; labeling for nisoldipine advises against strong inducers. If used, monitor blood pressure and titrate the dose.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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