Drug interactions
Nitazoxanide + Tolmetin
Severity: Minor
Nitazoxanide and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide is highly protein bound, as is tolmetin, so displacement is theoretically possible. No clinically meaningful effect has been established.
What this interaction means in plain words
Nitazoxanide and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitazoxanide belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No specific action is required; observe for increased NSAID adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Nitazoxanide with Tolmetin?
MediHelp rates the interaction as minor. Nitazoxanide and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide is highly protein bound, as is tolmetin, so displacement is theoretically possible. No clinically meaningful effect has been established.
How serious is the interaction between Nitazoxanide and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; observe for increased NSAID adverse effects.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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