Drug interactions
Nitazoxanide + Vincristine
Severity: Minor
Nitazoxanide and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite, tizoxanide, is highly protein bound, so displacement of other highly bound drugs is theoretically possible. Vincristine is only moderately protein bound, and no clinically meaningful interaction has been established.
What this interaction means in plain words
Nitazoxanide and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitazoxanide belongs to Anti Bacterial; Vincristine belongs to Oncology.
Why it happens
Theoretical competition for plasma protein binding; not shown to be clinically significant.
What to do
No specific action is needed beyond routine monitoring for vincristine toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Nitazoxanide with Vincristine?
MediHelp rates the interaction as minor. Nitazoxanide and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite, tizoxanide, is highly protein bound, so displacement of other highly bound drugs is theoretically possible. Vincristine is only moderately protein bound, and no clinically meaningful interaction has been established.
How serious is the interaction between Nitazoxanide and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring for vincristine toxicity.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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