Drug interactions
Nitrofurantoin + Regorafenib
Severity: Minor
Nitrofurantoin and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP, which handles nitrofurantoin. Exposure to nitrofurantoin could rise, though the clinical importance is uncertain.
What this interaction means in plain words
Nitrofurantoin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitrofurantoin belongs to Anti Bacterial; Regorafenib belongs to Oncology.
Why it happens
Inhibition of BCRP (ABCG2) by regorafenib, predicted to reduce efflux of nitrofurantoin.
What to do
No dose change is usually needed; watch for nitrofurantoin adverse effects such as nausea, neuropathy or pulmonary symptoms during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Regorafenib
Frequently asked questions
Can I take Nitrofurantoin with Regorafenib?
MediHelp rates the interaction as minor. Nitrofurantoin and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit the efflux transporter BCRP, which handles nitrofurantoin. Exposure to nitrofurantoin could rise, though the clinical importance is uncertain.
How serious is the interaction between Nitrofurantoin and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for nitrofurantoin adverse effects such as nausea, neuropathy or pulmonary symptoms during prolonged use.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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