Drug interactions
Nitroglycerin + Verapamil
Severity: Moderate
Nitroglycerin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil and nitroglycerin both reduce blood pressure through vasodilation, and orthostatic hypotension can occur. Verapamil also slows AV conduction and heart rate, which tends to blunt reflex tachycardia.
What this interaction means in plain words
Nitroglycerin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitroglycerin belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive vasodilation from nitric oxide-mediated venous dilation and calcium channel blockade-mediated arterial dilation.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug and counsel patients to sit when using sublingual nitroglycerin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nitroglycerin with Verapamil?
MediHelp rates the interaction as moderate. Nitroglycerin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil and nitroglycerin both reduce blood pressure through vasodilation, and orthostatic hypotension can occur. Verapamil also slows AV conduction and heart rate, which tends to blunt reflex tachycardia.
How serious is the interaction between Nitroglycerin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug and counsel patients to sit when using sublingual nitroglycerin.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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