Drug interactions
Norepinephrine + Prochlorperazine
Severity: Moderate
Norepinephrine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines block alpha-adrenergic receptors and can blunt the pressor response to norepinephrine. Higher vasopressor doses may be needed, and hypotension may be more difficult to correct. Arrhythmia risk from the sympathomimetic may also be additive in predisposed patients.
What this interaction means in plain words
Norepinephrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism via alpha-1 adrenergic receptor blockade by prochlorperazine.
What to do
Titrate norepinephrine to blood pressure response with continuous hemodynamic monitoring. Hold prochlorperazine in patients who are in shock if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Norepinephrine with Prochlorperazine?
MediHelp rates the interaction as moderate. Norepinephrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines block alpha-adrenergic receptors and can blunt the pressor response to norepinephrine. Higher vasopressor doses may be needed, and hypotension may be more difficult to correct. Arrhythmia risk from the sympathomimetic may also be additive in predisposed patients.
How serious is the interaction between Norepinephrine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine to blood pressure response with continuous hemodynamic monitoring. Hold prochlorperazine in patients who are in shock if possible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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