Drug interactions
Norethisterone + Voxelotor
Severity: Minor
Norethisterone and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may modestly increase norethisterone exposure. Clinically significant toxicity is unlikely because norethisterone has a wide therapeutic margin.
What this interaction means in plain words
Norethisterone and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norethisterone belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, slightly reducing norethisterone clearance.
What to do
No routine adjustment is needed. Ask about progestogenic adverse effects and reassess if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Norethisterone with Voxelotor?
MediHelp rates the interaction as minor. Norethisterone and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may modestly increase norethisterone exposure. Clinically significant toxicity is unlikely because norethisterone has a wide therapeutic margin.
How serious is the interaction between Norethisterone and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Ask about progestogenic adverse effects and reassess if they appear.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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