Drug interactions
Nortriptyline + Pregabalin
Severity: Moderate
Nortriptyline and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they increase sedation, dizziness and cognitive impairment, and CNS depressant combinations can contribute to respiratory depression, particularly in older adults or those with respiratory disease. Falls and impaired driving are practical concerns.
What this interaction means in plain words
Nortriptyline and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression from pharmacodynamic synergism.
What to do
Use the lowest effective doses and titrate gradually. Monitor for sedation and respiratory depression, especially with other CNS depressants or lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Nortriptyline with Pregabalin?
MediHelp rates the interaction as moderate. Nortriptyline and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they increase sedation, dizziness and cognitive impairment, and CNS depressant combinations can contribute to respiratory depression, particularly in older adults or those with respiratory disease. Falls and impaired driving are practical concerns.
How serious is the interaction between Nortriptyline and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually. Monitor for sedation and respiratory depression, especially with other CNS depressants or lung disease.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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