Drug interactions
Nortriptyline + Propylhexedrine
Severity: Minor
Nortriptyline and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics can modify sympathomimetic responses by blocking norepinephrine reuptake. Systemic absorption is usually small, but pressor effects may increase if overused.
What this interaction means in plain words
Nortriptyline and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nortriptyline belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake alters adrenergic response to the indirect sympathomimetic.
What to do
Limit use to labeled doses and short duration; monitor blood pressure if palpitations or headache occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Nortriptyline with Propylhexedrine?
MediHelp rates the interaction as minor. Nortriptyline and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is an inhaled sympathomimetic decongestant, and tricyclics can modify sympathomimetic responses by blocking norepinephrine reuptake. Systemic absorption is usually small, but pressor effects may increase if overused.
How serious is the interaction between Nortriptyline and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to labeled doses and short duration; monitor blood pressure if palpitations or headache occur.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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