Drug interactions
Nortriptyline + Sevoflurane
Severity: Moderate
Nortriptyline and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QT interval and cause CNS depression and hypotension. Together they may increase perioperative arrhythmia risk.
What this interaction means in plain words
Nortriptyline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, CNS depression and cardiovascular effects.
What to do
Review the ECG and electrolytes preoperatively and monitor the ECG and blood pressure during anesthesia. Inform the anesthesia team of tricyclic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Nortriptyline with Sevoflurane?
MediHelp rates the interaction as moderate. Nortriptyline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QT interval and cause CNS depression and hypotension. Together they may increase perioperative arrhythmia risk.
How serious is the interaction between Nortriptyline and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the ECG and electrolytes preoperatively and monitor the ECG and blood pressure during anesthesia. Inform the anesthesia team of tricyclic use.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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