Drug interactions
Nortriptyline + Stiripentol
Severity: Moderate
Nortriptyline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is sedating and can cause somnolence, which may add to nortriptyline sedation. Stiripentol also inhibits several CYP enzymes including CYP2D6, which may raise nortriptyline concentrations.
What this interaction means in plain words
Nortriptyline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus stiripentol inhibition of CYP-mediated nortriptyline metabolism.
What to do
Monitor sedation and tricyclic adverse effects, and consider reducing the nortriptyline dose. Check plasma levels if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Nortriptyline with Stiripentol?
MediHelp rates the interaction as moderate. Nortriptyline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is sedating and can cause somnolence, which may add to nortriptyline sedation. Stiripentol also inhibits several CYP enzymes including CYP2D6, which may raise nortriptyline concentrations.
How serious is the interaction between Nortriptyline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and tricyclic adverse effects, and consider reducing the nortriptyline dose. Check plasma levels if toxicity is suspected.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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