Drug interactions
Nortriptyline + Tedizolid
Severity: Major
Nortriptyline and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline inhibits serotonin and norepinephrine reuptake, and tedizolid weakly inhibits MAO. The combination could raise the risk of serotonin toxicity. Evidence is mainly theoretical and extrapolated from linezolid.
What this interaction means in plain words
Nortriptyline and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nortriptyline belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from reuptake inhibition by nortriptyline and weak MAO inhibition by tedizolid.
What to do
Prefer a non-serotonergic antibiotic. If the two must be given together, monitor closely for serotonin syndrome features and stop one drug if they occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Tedizolid?
MediHelp rates the interaction as major. Nortriptyline and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nortriptyline inhibits serotonin and norepinephrine reuptake, and tedizolid weakly inhibits MAO. The combination could raise the risk of serotonin toxicity. Evidence is mainly theoretical and extrapolated from linezolid.
How serious is the interaction between Nortriptyline and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antibiotic. If the two must be given together, monitor closely for serotonin syndrome features and stop one drug if they occur.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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