Drug interactions
Obinutuzumab + Trastuzumab deruxtecan
Severity: Moderate
Obinutuzumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia and immunosuppression, so combining them may increase the risk of infection. Trastuzumab deruxtecan can also cause interstitial lung disease, which may be harder to manage in an immunocompromised patient.
What this interaction means in plain words
Obinutuzumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Obinutuzumab belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects.
What to do
Monitor blood counts and watch for signs of infection and new respiratory symptoms. Hold or reduce doses as per labeling if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Obinutuzumab
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Obinutuzumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Obinutuzumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia and immunosuppression, so combining them may increase the risk of infection. Trastuzumab deruxtecan can also cause interstitial lung disease, which may be harder to manage in an immunocompromised patient.
How serious is the interaction between Obinutuzumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for signs of infection and new respiratory symptoms. Hold or reduce doses as per labeling if severe neutropenia occurs.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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