Drug interactions
Ocrelizumab + Tocilizumab
Severity: Moderate
Ocrelizumab and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are immunosuppressive: tocilizumab blocks IL-6 signaling and ocrelizumab depletes B cells. Combined use is expected to increase the risk of serious infections.
What this interaction means in plain words
Ocrelizumab and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Tocilizumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression through IL-6 receptor blockade and B-cell depletion.
What to do
Avoid unnecessary co-use and monitor closely for infection. Remember tocilizumab can blunt fever and CRP, so evaluate symptoms early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Ocrelizumab with Tocilizumab?
MediHelp rates the interaction as moderate. Ocrelizumab and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are immunosuppressive: tocilizumab blocks IL-6 signaling and ocrelizumab depletes B cells. Combined use is expected to increase the risk of serious infections.
How serious is the interaction between Ocrelizumab and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-use and monitor closely for infection. Remember tocilizumab can blunt fever and CRP, so evaluate symptoms early.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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