Drug interactions
Ocrelizumab + Trastuzumab
Severity: Minor
Ocrelizumab and Trastuzumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab is not itself strongly immunosuppressive, and it has no established interaction with ocrelizumab. Neutropenia reports relate to trastuzumab combined with cytotoxic chemotherapy rather than with a B-cell depleting antibody.
What this interaction means in plain words
Ocrelizumab and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ocrelizumab belongs to Central Nervous System; Trastuzumab belongs to Oncology.
Why it happens
No established mechanism; any additive infection risk is theoretical.
What to do
No specific action is needed beyond standard monitoring for infection and routine blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Ocrelizumab with Trastuzumab?
MediHelp rates the interaction as minor. Ocrelizumab and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab is not itself strongly immunosuppressive, and it has no established interaction with ocrelizumab. Neutropenia reports relate to trastuzumab combined with cytotoxic chemotherapy rather than with a B-cell depleting antibody.
How serious is the interaction between Ocrelizumab and Trastuzumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond standard monitoring for infection and routine blood counts.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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