Drug interactions
Octreotide + Posaconazole
Severity: Moderate
Octreotide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of posaconazole. The combined risk is greatest with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Octreotide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarisation, with octreotide-associated bradycardia as a contributor.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG and heart rate during co-therapy in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Posaconazole?
MediHelp rates the interaction as moderate. Octreotide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of posaconazole. The combined risk is greatest with electrolyte abnormalities or heart disease.
How serious is the interaction between Octreotide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG and heart rate during co-therapy in at-risk patients.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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