Drug interactions
Octreotide + Prochlorperazine
Severity: Moderate
Octreotide and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and octreotide also causes bradycardia, which adds to the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Octreotide and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia further increasing arrhythmia susceptibility.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and heart rate, and choose a non-QT-prolonging antiemetic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Prochlorperazine?
MediHelp rates the interaction as moderate. Octreotide and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and octreotide also causes bradycardia, which adds to the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Octreotide and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and heart rate, and choose a non-QT-prolonging antiemetic if the QTc becomes prolonged.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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