Drug interactions
Ofatumumab sc + Secukinumab
Severity: Moderate
Ofatumumab sc and Secukinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and secukinumab blocks IL-17A, so together they may increase susceptibility to infection. Their effects on immune function may overlap and persist after dosing stops.
What this interaction means in plain words
Ofatumumab sc and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and IL-17A blockade.
What to do
Monitor for signs of infection and avoid starting in active infection. Consider the duration of immune effects when switching between these agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Ofatumumab sc with Secukinumab?
MediHelp rates the interaction as moderate. Ofatumumab sc and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and secukinumab blocks IL-17A, so together they may increase susceptibility to infection. Their effects on immune function may overlap and persist after dosing stops.
How serious is the interaction between Ofatumumab sc and Secukinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and avoid starting in active infection. Consider the duration of immune effects when switching between these agents.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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