Drug interactions
Ofatumumab sc + Teriflunomide
Severity: Moderate
Ofatumumab sc and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect immune function, so using them together or in close sequence may add to the risk of infection. Teriflunomide has a very long elimination half-life, so its immunologic effects persist after discontinuation.
What this interaction means in plain words
Ofatumumab sc and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion by ofatumumab and inhibition of lymphocyte proliferation by teriflunomide.
What to do
When switching, consider the long persistence of teriflunomide and whether an accelerated elimination procedure is warranted; monitor for infections and check blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Ofatumumab sc with Teriflunomide?
MediHelp rates the interaction as moderate. Ofatumumab sc and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect immune function, so using them together or in close sequence may add to the risk of infection. Teriflunomide has a very long elimination half-life, so its immunologic effects persist after discontinuation.
How serious is the interaction between Ofatumumab sc and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When switching, consider the long persistence of teriflunomide and whether an accelerated elimination procedure is warranted; monitor for infections and check blood counts.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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