Drug interactions
Ofloxacin + Ozanimod
Severity: Moderate
Ofloxacin and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and delay AV conduction at initiation, and bradycardia increases the risk of torsades de pointes with QT-prolonging drugs such as ofloxacin. Together they may raise arrhythmia risk.
What this interaction means in plain words
Ofloxacin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.
Why it happens
Ozanimod-related bradycardia combined with ofloxacin-induced QT prolongation gives additive proarrhythmic risk.
What to do
Consider a non-QT-prolonging antibiotic when starting ozanimod. If both are needed, obtain an ECG and monitor heart rate and rhythm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ofloxacin with Ozanimod?
MediHelp rates the interaction as moderate. Ofloxacin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and delay AV conduction at initiation, and bradycardia increases the risk of torsades de pointes with QT-prolonging drugs such as ofloxacin. Together they may raise arrhythmia risk.
How serious is the interaction between Ofloxacin and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic when starting ozanimod. If both are needed, obtain an ECG and monitor heart rate and rhythm.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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