Drug interactions
Ofloxacin + Panobinostat
Severity: Major
Ofloxacin and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together raises the risk of torsades de pointes and other serious ventricular arrhythmias. Panobinostat labeling advises against combining it with agents known to prolong QTc.
What this interaction means in plain words
Ofloxacin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ofloxacin belongs to Anti Bacterial; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through delayed cardiac repolarization.
What to do
Avoid the combination and choose a non-QT-prolonging antibacterial. If it cannot be avoided, obtain a baseline ECG, monitor serial ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Ofloxacin with Panobinostat?
MediHelp rates the interaction as major. Ofloxacin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together raises the risk of torsades de pointes and other serious ventricular arrhythmias. Panobinostat labeling advises against combining it with agents known to prolong QTc.
How serious is the interaction between Ofloxacin and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibacterial. If it cannot be avoided, obtain a baseline ECG, monitor serial ECGs and correct potassium and magnesium.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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