Drug interactions
Ofloxacin + Tiotropium-olodaterol
Severity: Moderate
Ofloxacin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can prolong the QT interval, though less than some other fluoroquinolones, and olodaterol may add to arrhythmic risk via hypokalemia and sympathetic stimulation. The risk is greatest with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Ofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia.
What to do
Check and correct potassium and magnesium and consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Ofloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can prolong the QT interval, though less than some other fluoroquinolones, and olodaterol may add to arrhythmic risk via hypokalemia and sympathetic stimulation. The risk is greatest with electrolyte disturbances or cardiac disease.
How serious is the interaction between Ofloxacin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium and consider an ECG in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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