Drug interactions
Ofloxacin + Trazodone
Severity: Moderate
Ofloxacin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and together they may increase the risk of torsades de pointes. The risk is higher in patients with heart disease, electrolyte imbalance or other QT-prolonging therapy.
What this interaction means in plain words
Ofloxacin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Trazodone belongs to Central Nervous System.
Why it happens
Additive inhibition of cardiac potassium channels prolonging repolarization.
What to do
Obtain an ECG if the patient has cardiac risk factors and correct low potassium or magnesium. Consider an alternative antibiotic when other risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ofloxacin with Trazodone?
MediHelp rates the interaction as moderate. Ofloxacin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and together they may increase the risk of torsades de pointes. The risk is higher in patients with heart disease, electrolyte imbalance or other QT-prolonging therapy.
How serious is the interaction between Ofloxacin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if the patient has cardiac risk factors and correct low potassium or magnesium. Consider an alternative antibiotic when other risks are present.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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