Drug interactions
Olanzapine + Posaconazole
Severity: Moderate
Olanzapine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a low but real potential for QT prolongation, which could be additive with posaconazole. Posaconazole does not meaningfully inhibit CYP1A2, the main olanzapine pathway, so the concern is mainly pharmacodynamic.
What this interaction means in plain words
Olanzapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and electrolytes and monitor the QTc, especially if other risk factors or QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Posaconazole?
MediHelp rates the interaction as moderate. Olanzapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a low but real potential for QT prolongation, which could be additive with posaconazole. Posaconazole does not meaningfully inhibit CYP1A2, the main olanzapine pathway, so the concern is mainly pharmacodynamic.
How serious is the interaction between Olanzapine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc, especially if other risk factors or QT-prolonging drugs are present.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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