Drug interactions
Olanzapine + Prochlorperazine
Severity: Moderate
Olanzapine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together increases dopamine blockade, raising the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and tardive dyskinesia. Sedation and QT prolongation can also be additive.
What this interaction means in plain words
Olanzapine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 receptor antagonism with additive sedative and cardiac repolarization effects.
What to do
Avoid routine duplication of antipsychotics; if prochlorperazine is used as an antiemetic, use the lowest dose for the shortest time. Monitor for movement disorders, sedation, fever and rigidity, and obtain an ECG if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Prochlorperazine?
MediHelp rates the interaction as moderate. Olanzapine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two antipsychotics together increases dopamine blockade, raising the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and tardive dyskinesia. Sedation and QT prolongation can also be additive.
How serious is the interaction between Olanzapine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of antipsychotics; if prochlorperazine is used as an antiemetic, use the lowest dose for the shortest time. Monitor for movement disorders, sedation, fever and rigidity, and obtain an ECG if risk factors are present.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
