Drug interactions
Olanzapine + Propofol
Severity: Moderate
Olanzapine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can enhance the sedative and hypotensive effects of propofol, so lower propofol doses may be sufficient. Deeper sedation and hemodynamic instability may occur during anesthesia or procedural sedation.
What this interaction means in plain words
Olanzapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and vasodilatory hypotension.
What to do
Titrate propofol cautiously to effect and monitor blood pressure and respiration continuously. Inform the anesthesia team that the patient takes olanzapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Propofol
Frequently asked questions
Can I take Olanzapine with Propofol?
MediHelp rates the interaction as moderate. Olanzapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can enhance the sedative and hypotensive effects of propofol, so lower propofol doses may be sufficient. Deeper sedation and hemodynamic instability may occur during anesthesia or procedural sedation.
How serious is the interaction between Olanzapine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously to effect and monitor blood pressure and respiration continuously. Inform the anesthesia team that the patient takes olanzapine.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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