Drug interactions
Olanzapine + Vilazodone
Severity: Moderate
Olanzapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone combined with olanzapine, which has serotonin and dopamine receptor antagonism, may rarely lead to serotonin syndrome or neuroleptic malignant syndrome. The combination is often used in practice but warrants awareness.
What this interaction means in plain words
Olanzapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with dopamine and serotonin receptor antagonism, a pharmacodynamic interaction.
What to do
Monitor for tremor, clonus, hyperthermia, rigidity and autonomic instability, especially at initiation or dose increases. Withdraw the agents and give supportive care if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Vilazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Vilazodone?
MediHelp rates the interaction as moderate. Olanzapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone combined with olanzapine, which has serotonin and dopamine receptor antagonism, may rarely lead to serotonin syndrome or neuroleptic malignant syndrome. The combination is often used in practice but warrants awareness.
How serious is the interaction between Olanzapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, clonus, hyperthermia, rigidity and autonomic instability, especially at initiation or dose increases. Withdraw the agents and give supportive care if toxicity is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
