Drug interactions
Olanzapine / samidorphan + Umeclidinium
Severity: Moderate
Olanzapine / samidorphan and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has antimuscarinic activity and its labeling warns about severe gastrointestinal hypomotility with other anticholinergic drugs. Adding umeclidinium may further increase constipation, urinary retention, dry mouth and tachycardia, though inhaled systemic exposure is low.
What this interaction means in plain words
Olanzapine / samidorphan and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism leading to reduced gut motility.
What to do
Monitor bowel function and urinary symptoms. Use a bowel regimen and review therapy if constipation or ileus develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Frequently asked questions
Can I take Olanzapine / samidorphan with Umeclidinium?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has antimuscarinic activity and its labeling warns about severe gastrointestinal hypomotility with other anticholinergic drugs. Adding umeclidinium may further increase constipation, urinary retention, dry mouth and tachycardia, though inhaled systemic exposure is low.
How serious is the interaction between Olanzapine / samidorphan and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms. Use a bowel regimen and review therapy if constipation or ileus develops.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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