Drug interactions
Olanzapine / samidorphan + Vilazodone
Severity: Moderate
Olanzapine / samidorphan and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation and orthostatic hypotension, and vilazodone can add to drowsiness and dizziness. Serotonergic and dopamine-blocking effects together also carry a rare risk of serotonin syndrome or NMS.
What this interaction means in plain words
Olanzapine / samidorphan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects, with pharmacodynamic serotonergic and dopaminergic interplay.
What to do
Monitor for sedation, orthostatic blood pressure changes and signs of serotonin toxicity. Counsel patients to rise slowly and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Vilazodone?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation and orthostatic hypotension, and vilazodone can add to drowsiness and dizziness. Serotonergic and dopamine-blocking effects together also carry a rare risk of serotonin syndrome or NMS.
How serious is the interaction between Olanzapine / samidorphan and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic blood pressure changes and signs of serotonin toxicity. Counsel patients to rise slowly and avoid alcohol.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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