Drug interactions
Oliceridine + Pentazocine
Severity: Major
Oliceridine and Pentazocine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentazocine, a mixed agonist-antagonist, may reduce the analgesic effect of oliceridine and may precipitate withdrawal in patients physically dependent on opioids. Respiratory depression can also be additive.
What this interaction means in plain words
Oliceridine and Pentazocine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Pentazocine belongs to Musculoskeletal.
Why it happens
Partial agonist-antagonist activity at mu receptors competes with a full mu agonist, plus additive opioid effects.
What to do
Avoid concurrent use. If both are used, monitor for withdrawal, inadequate analgesia and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Pentazocine?
MediHelp rates the interaction as major. Oliceridine and Pentazocine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentazocine, a mixed agonist-antagonist, may reduce the analgesic effect of oliceridine and may precipitate withdrawal in patients physically dependent on opioids. Respiratory depression can also be additive.
How serious is the interaction between Oliceridine and Pentazocine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If both are used, monitor for withdrawal, inadequate analgesia and respiratory depression.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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