Drug interactions
Oliceridine + Solifenacin
Severity: Moderate
Oliceridine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gut motility and can cause urinary retention, and combining them with an antimuscarinic increases the risk of severe constipation, paralytic ileus and urinary retention.
What this interaction means in plain words
Oliceridine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Solifenacin belongs to Genitourinary.
Why it happens
Additive reduction in gastrointestinal and bladder motility via opioid and muscarinic receptor effects.
What to do
Monitor for urinary retention, constipation and abdominal distension, and start a prophylactic bowel regimen when the opioid is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Solifenacin?
MediHelp rates the interaction as moderate. Oliceridine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gut motility and can cause urinary retention, and combining them with an antimuscarinic increases the risk of severe constipation, paralytic ileus and urinary retention.
How serious is the interaction between Oliceridine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and abdominal distension, and start a prophylactic bowel regimen when the opioid is given.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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