Drug interactions
Oliceridine + Succinylcholine
Severity: Moderate
Oliceridine and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine causes sedation and respiratory depression, and succinylcholine causes paralysis, so respiratory compromise is possible if ventilation is not supported. In anesthesia this is managed with airway control, but residual depression after recovery remains a concern.
What this interaction means in plain words
Oliceridine and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from central opioid effects and neuromuscular blockade.
What to do
Use only with secured ventilatory support, give the lowest effective oliceridine dose, and monitor respiration and sedation after recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Succinylcholine?
MediHelp rates the interaction as moderate. Oliceridine and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine causes sedation and respiratory depression, and succinylcholine causes paralysis, so respiratory compromise is possible if ventilation is not supported. In anesthesia this is managed with airway control, but residual depression after recovery remains a concern.
How serious is the interaction between Oliceridine and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with secured ventilatory support, give the lowest effective oliceridine dose, and monitor respiration and sedation after recovery.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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