Drug interactions
Oliceridine + Zolmitriptan
Severity: Moderate
Oliceridine and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic opioids have been linked to serotonin syndrome when combined with triptans. Oliceridine has limited direct serotonergic action, so the risk is probably low.
What this interaction means in plain words
Oliceridine and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect; oliceridine's contribution is not well established.
What to do
Monitor for serotonin syndrome when used together, especially after dose changes. Stop the serotonergic agents if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Zolmitriptan?
MediHelp rates the interaction as moderate. Oliceridine and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic opioids have been linked to serotonin syndrome when combined with triptans. Oliceridine has limited direct serotonergic action, so the risk is probably low.
How serious is the interaction between Oliceridine and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome when used together, especially after dose changes. Stop the serotonergic agents if symptoms occur.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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